Born in St. Louis, Missouri, Moore received an MFA from Yale University before settling in Philadelphia where he worked for over four decades. His paintings are included in major collections such as the Art Institute of Chicago; the Metropolitan Museum of Art; the Museum of Fine Arts, Boston; the Pennsylvania Academy of Fine Arts; the Philadelphia Museum of Art; Yale University Art Gallery; and many others. Formerly the Gutman Professor and Chair of Fine Arts at the University of Pennsylvania from 1999 to 2009, he previously taught at Boston University, the Tyler School of Art at Temple University, and the University of California, Berkeley. The Maine Center for Contemporary Art in Rockland featured a survey of his work in 2018. He currently lives and works in Belfast, Maine.